Melatonin

Melatonin, N-acetyl-5-methoxytryptamine, is an endogenous indolamine hormone that is released by the pineal gland in significant quantities in a circadian pattern.
Uses and Benefits:

Melatonin is most often used for insomnia and jet lag. It is also used by night-shift workers and for blind entrainment (to regulate sleep patterns in those who are blind). It has been researched as an oral contraceptive, antioxidant, and anticancer agent.
Pharmacology:

Regulation of melatonin secretion corresponds to the habitual sleep-wake hours in humans. Thus, melatonin secretion increases during nightfall, 9 PM-4 AM, and levels gradually decline until daylight. Exogenous melatonin has been used to supplement endogenous melatonin production for a number of indications.
Clinical Trials:

. Insomnia-Several randomized, double-blind clinical trials have been conducted evaluating the role of oral melatonin in patients with insomnia. These studies all suggest melatonin im

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