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This book describes a PhD research in which the regulatory sequences of IGF2 (P3 and P4 promoters) were used to induce killing of cancer cells in culture or cell of mouse and rat bladder TCCs and of rat colon metastasis to the liver. IGF2 gene was found to be differentially overexpressed in malignant compaired to normal bladder tissue. Moreover, IGF2 mRNA and protein levels were previously shown to be highly upregulated in primary colorectal cancer … More >>

Gene therapy of bladder cancer and colorectal metastasis in the liver: Isulin like growth factor 2 P3 and P4 regulatory sequences controlled suicidal therapy of cancer cells

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